Yes, there's a lot to wrap up/tie together. I'm assuming that Delphine will show up as a reward to Cosima near the end in a cameo appearance, and that Kira's psychic powers will be a long term thing, i.e. not something that needs to resolved this season. Mind you, I suspect her ability to sense whatever the other clones are feeling might come in handy if/when Rachel at any point plans to doublecross Sarah, but that would actually be so predictable that I hope the show won't go there.

What I think needs/will be wrapped up this season: the thing with the bug. "Rewriting DNA" is such a vague goal - for what? That's something yet to be revealed and dealt with, and hopefully it will explain why Evie wants Sarah dead.

Maybe Rachel has to do something to get it to play correctly, and then she'll understand the message behind it.

Yes, that would make sense, in a sci fi way. I do wonder whether Kira's copy of Dr. Moreau will come in handy again. And/or Kira herself, but if the trigger were simply Rachel interacting with a child in a non-hostile fashion, her times with Charlotte would have done the trick.

Speaking of Charlotte, since she wasn't directly cloned from Kendall's DNA but from Rachel's, I wonder whether Kira can sense her as well?